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The proportion of CD161 on CD56+NK cells in peripheral circulation associates with clinical features and disease activity of primary Sjögren’s syndrome
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  • Cuiping Liu,
  • ping zhao,
  • Yanhong Yang,
  • Saizhe Song,
  • wei cheng,
  • cheng peng,
  • Xin Chang,
  • Jian Wu
Cuiping Liu
First Affiliated Hospital of Soochow University Jiangsu Key Laboratory of Clinical Immunology

Corresponding Author:liucuiping@suda.edu.cn

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ping zhao
The First Affiliated Hospital of Bengbu Medical College Department of Rheumatology
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Yanhong Yang
First Affiliated Hospital of Soochow University Jiangsu Key Laboratory of Clinical Immunology
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Saizhe Song
First Affiliated Hospital of Soochow University Jiangsu Key Laboratory of Clinical Immunology
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wei cheng
First Affiliated Hospital of Soochow University
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cheng peng
First Affiliated Hospital of Soochow University
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Xin Chang
Soochow University Affiliated No 1 People's Hospital
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Jian Wu
First Affiliated Hospital of Soochow University
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Abstract

Objectives:The purpose of this study was to examine the proportion of CD161 on CD56+Natural Killer(NK) cells in peripheral blood of primary Sjögren’s syndrome(pSS) and investigate its clinical relevance of pSS. Methods:The proportion of CD56+NK cells and CD161 on CD56+NK cells was detected by flow cytometry in 31 pSS patients and 29 healthy controls (HCs). The correlations between proportion of CD161+CD56+NK cells and clinical features and disease activity of pSS were further analysed. Meanwhile, we drew the receiver operating characteristic(ROC) curve to evaluate the diagnostic value of CD161+CD56+NK cells in pSS. Results: The proportion of CD56+ NK cells and CD161+CD56+NK cells decreased markly in pSS patients compared to HCs. The correlation analysis showed that proportion of CD161+CD56+NK cells negatively correlated with WBC,IgA,IgM,IgG,ESSRPI and ESSDAI,and positively correlated with complement C4.The proportion of CD161+CD56+NK cells in pSS patients with decayed tooth, fatigue, arthralgia, skin involvement, primary biliary cirrhosis(PBC),interstitial lung disease(ILD), anti-SSA/Ro60 positive, anti-SSB positive and high IgG was lower than that in negative patients. Furthermore, compared with innactive patients,the proportion of CD161+CD56+NK cells decreased obviously in active patients. The area under the curve(AUC)was 0.7375(P=0.0016),the results indicated that CD161+CD56+NK cells had certain diagnostic value for pSS. Conclusion: This study suggested that the proportion of CD56+NK cells and CD161+CD56+NK cells decreased significantly in pSS patients,and the proportion of CD161+CD56+NK cells negatively associated with the clinical features and disease activity of pSS patients. The CD161+CD56+NK cells may present as a potential target for therapy and a biomarker of disease activity in pSS .
Submitted to Immunity, Inflammation and Disease
13 Mar 2024Submission Checks Completed
13 Mar 2024Assigned to Editor
13 Mar 2024Review(s) Completed, Editorial Evaluation Pending
13 Mar 2024Reviewer(s) Assigned
22 Mar 2024Editorial Decision: Accept