Variables included in deriving the phenotypes
We included a list of 47 variables, which were selected based on
clinical experience and previous studies. This comprehensive list of
variables was included to capture a full representation of the clinical
presentation, pathophysiological mechanisms, and potential risk factors
related to asthma. The variables were grouped as follows: (1)
demographics/triggers/risk factors; (2) symptom profiles; (3) measures
of pulmonary function; (4) disease prognosis and severity indicators;
and (5) measures of inflammation. All variables were self -reported by
participants except for lung function, reversibility, measures of lung
diffusion capacity, and inflammation biomarkers which were measured
objectively in the clinic. A detailed list of all variables is presented
in the Supplementary file .
Statistical analysis