Risk Factors for Sudden Cardiac Arrest Among Hispanic or Latino Adults
in Southern California: Ventura PRESTO and HCHS/SOL16
|
Case-control study |
Chronic kidney disease was the top predictor of
sudden cardiac arrest risk in Hispanic adult subjects in this
study. |
Comprehensive Genetic Characterization of a Spanish Brugada Syndrome
Cohort24
|
Retrospective cohort study |
This study
identified 14 Brugada syndrome-susceptibility genes in a Spanish cohort,
revealing a higher pathogenic variation discovery yield (32.7%)
compared to other European BrS cohorts. |
Ethnic Differences in Genetic Ion Channelopathies Associated with Sudden
Cardiac Death: A Systematic Review and Meta-Analysis25
|
Systematic review and meta-analysis |
There are significant ethnic
variations in alleles associated with SCD, with Asians having the
highest mean allele frequencies for NOS1AP and SCN5A,
Caucasians for KCNH2, and Hispanics for
KCNQ1. |
GWAS of the electrocardiographic QT interval in Hispanics/Latinos
generalizes previously identified loci and identifies
population-specific signals26
|
Meta-analysis |
This
study identified 41 genome-wide significant SNPs across 13 known QT loci
and revealed potential novel, population-specific variants at
SCN5A and KCNE1. |
Multiple independent genetic factors at NOS1AP modulate the QT interval
in a multi-ethnic population27
|
Retrospective cohort
study |
This study on genetic variants in NOS1AP with QT interval
to a multi-ethnic population, reveals a significant association in
Whites and Blacks and a potential association in
Hispanics. |
Associations between NOS1AP single nucleotide polymorphisms (SNPs) and
QT interval duration in four racial/ethnic groups in the Multi-Ethnic
Study of Atherosclerosis (MESA)28
|
Retrospective
cohort study |
The study explored the effects of NOS1AP variants
on QT interval duration in a diverse cohort, finding stronger
associations in Caucasians, weaker evidence in Hispanics and Chinese,
and potential novel associations at the 3’ end of NOS1AP in
Chinese participants. |
Fine mapping of QT interval regions in global populations refines
previously identified QT interval loci and identifies signals unique to
African and Hispanic descent populations29
|
Fine-mapping study |
The study fine-mapped 16 QT loci in AA and
Hispanic/Latino populations, revealing shared and novel
population-specific QT signals, emphasizing gene regulatory dysfunction
in QT prolongation. |
Cardiac arrest with ”pseudo-Brugada” ECG pattern in the setting of a
coronary artery anomaly22
|
Case report and literature
review |
The study describes a case of a Hispanic man with ventricular
fibrillation and BrS, whose anomalous origin of the right coronary
artery was surgically corrected, leading to the normalization of the
Brugada ECG pattern. |
A Case of Brugada Syndrome Masquerading as Acute Coronary Syndrome in a
Hispanic Male23
|
Case report |
This case report
described the management of a 58-year-old male with BrS manifesting
similarly to acute coronary syndrome after ruling out structural heart
diseases. |
Prevalence of atrial fibrillation and association with clinical,
sociocultural, and ancestral correlates among Hispanic/Latinos: The
Hispanic Community Health Study/Study of Latinos14
|
Population-based prospective cohort study |
The study found a low
overall AF prevalence (1.0%) in a diverse Hispanic/Latino population,
indicating varying risks across ethnic backgrounds, with individuals of
Dominican and Puerto Rican heritage having higher AF risks than those of
Mexican background. |
Evaluation of Sudden Cardiac Arrest by Race/Ethnicity Among Residents of
Ventura County, California, 2015-202017
|
Prospective
cohort study |
The study found that the burden of sudden cardiac arrest
was similar in Hispanic and White cohorts and lower in Asian cohort and
identified shared SCA risk factors among Asian and Hispanic
populations. |
Validation of PR interval length as a criterion for development of
atrial fibrillation in non-Hispanic whites, African Americans and
Hispanics18
|
Retrospective epidemiological study |
The study validates a PR interval of 200ms as a criterion for predicting
AF in AA and Hispanics, but suggests that this value may be less
sensitive in predicting AF in AA compared to non-Hispanic
Whites. |
Are sedentary behavior and physical activity independently associated
with cardiometabolic benefits? The Hispanic Community Health Study/Study
of Latinos33
|
Prospective cohort study |
Hispanics/Latinos without cardiometabolic disease and those who met
guidelines for low-to-moderate physical activity experienced a
significant decline in LDL-cholesterol and lower fasting glucose levels
indicating a population-specific benefit of lifestyle determinants of
health. |
Confronting the Growing Crisis of Cardiovascular Disease and Heart
Health Among Aboriginal Peoples in Canada13
|
Literature review |
This literature review article discusses the
increasing burden of CVD among Canadian Aboriginal peoples, attributed
to dietary changes and reduced physical activity. |
The Genetics of Cardiovascular Disease in Canadian and International
Aboriginal Populations12
|
Literature review |
This
study emphasizes the genetic factors influencing CVD in Aboriginal
populations, noting distinctions in disease rates, including higher
incidences of congenital heart malformations and LQTS in specific
communities. |
Cardiovascular Disease Burden and Outcomes Among American Indian and
Alaska Native Medicare Beneficiaries11
|
Population-based cohort study |
This study discusses the significant
burden of CVD and cardiometabolic risk factors among American Indian and
Alaska Native Medicare beneficiaries. |
American Indians and atrial fibrillation34
|
Literature review |
This study discusses the heightened risk of AF and
AF-related stroke in the American Indian population. |
Atrial fibrillation in Indigenous and non-Indigenous Australians: a
cross-sectional study35
|
Retrospective
cross-sectional study |
This study discusses the age-dependent
prevalence of AF in Indigenous and non-Indigenous Australians,
highlighting significantly higher rates among young Indigenous
Australians. |
Screening for Atrial Fibrillation in American Indian Adults in a Tribal
Primary Care Clinic36
|
Prospective cohort study |
This study demonstrates the feasibility and efficacy of opportunistic,
mobile single-lead ECG screening for AF in American Indian adults,
revealing a higher prevalence of AF than in the usual care group,
especially among those under 65, emphasizing the potential benefits of
earlier AF screening in this population. |
Comparison of QRS Duration and Associated Cardiovascular Events in
American Indian Men Versus Women (The Strong Heart
Study)37
|
Prospective cohort study |
This cohort
study compares American Indian men and women, showing that elevated QRS
duration is an independent predictor of CVD in women, particularly
associated with higher risks of coronary heart disease and myocardial
infarction. |
A KCNQ1 V205M missense mutation causes a high rate of long QT syndrome
in a First Nations community of northern British Columbia: a
community-based approach to understanding the impact38
|
Comparative study |
This study, conducted in a remote Canadian First
Nations community, identifies a novel KCNQ1 mutation (V205M)
associated with hereditary LQTS, leading to variable clinical
expression. |