ICD in Cardiac Sarcoidosis: Variables associated with appropriate
therapy, inappropriate therapy, and device complications
Abstract
Introduction: Those with cardiac sarcoidosis (CS) are at risk
of sudden cardiac death (SCD), which may be prevented using an
implantable cardioverter defibrillator (ICD). There is limited data
available that follows the post-procedural outcomes of patients with
cardiac sarcoidosis (CS) who have had an ICD implanted. Areas
Covered: This review will highlight studies that focus on both
appropriate and inappropriate therapies in those with an ICD, as well as
device complications in this group. There were several variables
inclusive of age, gender, ventricular characteristics and findings on
cardiac imaging that were investigated and discussed as influencing
factors in predicting appropriate and inappropriate therapies.
Conclusions: Adverse events in those with an ICD and CS were
minimally reported in the literature. Individuals diagnosed with CS are
at high risk of ventricular arrhythmia, with comparable rates of
appropriate therapy but higher incidence of side effects and
inappropriate therapy. The younger average age of CS patients in
comparison to other ICD cohorts warrants the need for further,
large-scale, prospective trials with periodic interim follow-ups focused
on those with this condition.