Background: Over-the-counter (OTC) medications are widely available in the market without a prescription. Pain, coughs and colds, diarrhoea, constipation, acne, and other ailments are all treated with over-the-counter medications. The implications of such actions should always be made clear to the community, along with efforts to prevent them. Objective: This assessment aims to evaluate AJK medical students’ knowledge, attitudes, and behaviours around self-medication using over-the-counter (OTC) medications. Methods: A study was carried out with AJK medical students. Through WhatsApp, an online survey was sent to the students of the first year to fifth year of each of the four medical colleges in AJK. The information was gathered in 2023 between June 25 and July 31,. Applying SPSS-25, data analysis was done. Results: 372 individuals reported their responses. Last year, 65.3% of people practiced self-medication. Analgesics and antipyretics were the most often used medications (55.9%). Fever, discomfort, and toothache were the symptoms that medical students self-medicated for the most (58.1%). Conclusion: In a nutshell self-medication with OTC medications is a contemporary issue. Medical students who lack the necessary clinical expertise and understanding to self-medicate. They alter the course of therapy frequently in order to suit their schedules, which lowers the effectiveness of the medications.