Table 1. Candidate genes involved in a direct response to
Urtica and Ribes. Genes with at least five-fold
differential expression between Urtica and Ribes
treatments 17 hours after a switch to Host 2 compared to controls
remaining on Host 1 (i.e., UdUd - UdRu or RuRu -
RuUd). Gene name and functional description are given for each
gene. Furthermore, names of orthologs genes in Heliconius
melpomene and the corresponding gene description are given. Gene
function was determined based on the functional annotations of both
datasets. Moreover, the regulation of gene expression on Host 2 after
the switch is stated. Each gene was classified based on the categories
of transcriptional changes shown in figure 2. Note that an upregulation
on one host can be interpreted as a downregulation on the alternative
host. Genes in bold were highly upregulated on the same host also in the
earlier study (without a switch; Celorio-Mancera et al. 2023) .
NA = not annotated. Each gene was classified based on the categories of
transcriptional changes shown in figure 2. Ud=Urtica
dioica, Ru=Ribes uva-crispa
|
Table 1.
Candidate genes involved in a direct response to Urtica and
Ribes. Genes with at least five-fold differential expression
between Urtica and Ribes treatments 17 hours after a
switch to Host 2 compared to controls remaining on Host 1 (i.e.,
UdUd - UdRu or RuRu - RuUd). Gene name and
functional description are given for each gene. Furthermore, names of
orthologs genes in Heliconius melpomene and the corresponding
gene description are given. Gene function was determined based on the
functional annotations of both datasets. Moreover, the regulation of
gene expression on Host 2 after the switch is stated. Each gene was
classified based on the categories of transcriptional changes shown in
figure 2. Note that an upregulation on one host can be interpreted as a
downregulation on the alternative host. Genes in bold were highly
upregulated on the same host also in the earlier study (without a
switch; Celorio-Mancera et al. 2023) . NA = not annotated. Each
gene was classified based on the categories of transcriptional changes
shown in figure 2. Ud=Urtica dioica,
Ru=Ribes uva-crispa
|
Table 1. Candidate genes
involved in a direct response to Urtica and Ribes. Genes
with at least five-fold differential expression between Urtica
and Ribes treatments 17 hours after a switch to Host 2 compared
to controls remaining on Host 1 (i.e., UdUd - UdRu or
RuRu - RuUd). Gene name and functional description are
given for each gene. Furthermore, names of orthologs genes in
Heliconius melpomene and the corresponding gene description are
given. Gene function was determined based on the functional annotations
of both datasets. Moreover, the regulation of gene expression on Host 2
after the switch is stated. Each gene was classified based on the
categories of transcriptional changes shown in figure 2. Note that an
upregulation on one host can be interpreted as a downregulation on the
alternative host. Genes in bold were highly upregulated on the same host
also in the earlier study (without a switch; Celorio-Mancera et
al. 2023) . NA = not annotated. Each gene was classified based on the
categories of transcriptional changes shown in figure 2.
Ud=Urtica dioica, Ru=Ribes uva-crispa
|
Table 1. Candidate genes involved in a direct response to
Urtica and Ribes. Genes with at least five-fold
differential expression between Urtica and Ribes
treatments 17 hours after a switch to Host 2 compared to controls
remaining on Host 1 (i.e., UdUd - UdRu or RuRu -
RuUd). Gene name and functional description are given for each
gene. Furthermore, names of orthologs genes in Heliconius
melpomene and the corresponding gene description are given. Gene
function was determined based on the functional annotations of both
datasets. Moreover, the regulation of gene expression on Host 2 after
the switch is stated. Each gene was classified based on the categories
of transcriptional changes shown in figure 2. Note that an upregulation
on one host can be interpreted as a downregulation on the alternative
host. Genes in bold were highly upregulated on the same host also in the
earlier study (without a switch; Celorio-Mancera et al. 2023) .
NA = not annotated. Each gene was classified based on the categories of
transcriptional changes shown in figure 2. Ud=Urtica
dioica, Ru=Ribes uva-crispa
|
Table 1.
Candidate genes involved in a direct response to Urtica and
Ribes. Genes with at least five-fold differential expression
between Urtica and Ribes treatments 17 hours after a
switch to Host 2 compared to controls remaining on Host 1 (i.e.,
UdUd - UdRu or RuRu - RuUd). Gene name and
functional description are given for each gene. Furthermore, names of
orthologs genes in Heliconius melpomene and the corresponding
gene description are given. Gene function was determined based on the
functional annotations of both datasets. Moreover, the regulation of
gene expression on Host 2 after the switch is stated. Each gene was
classified based on the categories of transcriptional changes shown in
figure 2. Note that an upregulation on one host can be interpreted as a
downregulation on the alternative host. Genes in bold were highly
upregulated on the same host also in the earlier study (without a
switch; Celorio-Mancera et al. 2023) . NA = not annotated. Each
gene was classified based on the categories of transcriptional changes
shown in figure 2. Ud=Urtica dioica,
Ru=Ribes uva-crispa
|
Table 1. Candidate genes
involved in a direct response to Urtica and Ribes. Genes
with at least five-fold differential expression between Urtica
and Ribes treatments 17 hours after a switch to Host 2 compared
to controls remaining on Host 1 (i.e., UdUd - UdRu or
RuRu - RuUd). Gene name and functional description are
given for each gene. Furthermore, names of orthologs genes in
Heliconius melpomene and the corresponding gene description are
given. Gene function was determined based on the functional annotations
of both datasets. Moreover, the regulation of gene expression on Host 2
after the switch is stated. Each gene was classified based on the
categories of transcriptional changes shown in figure 2. Note that an
upregulation on one host can be interpreted as a downregulation on the
alternative host. Genes in bold were highly upregulated on the same host
also in the earlier study (without a switch; Celorio-Mancera et
al. 2023) . NA = not annotated. Each gene was classified based on the
categories of transcriptional changes shown in figure 2.
Ud=Urtica dioica, Ru=Ribes uva-crispa
|
Table 1. Candidate genes involved in a direct response to
Urtica and Ribes. Genes with at least five-fold
differential expression between Urtica and Ribes
treatments 17 hours after a switch to Host 2 compared to controls
remaining on Host 1 (i.e., UdUd - UdRu or RuRu -
RuUd). Gene name and functional description are given for each
gene. Furthermore, names of orthologs genes in Heliconius
melpomene and the corresponding gene description are given. Gene
function was determined based on the functional annotations of both
datasets. Moreover, the regulation of gene expression on Host 2 after
the switch is stated. Each gene was classified based on the categories
of transcriptional changes shown in figure 2. Note that an upregulation
on one host can be interpreted as a downregulation on the alternative
host. Genes in bold were highly upregulated on the same host also in the
earlier study (without a switch; Celorio-Mancera et al. 2023) .
NA = not annotated. Each gene was classified based on the categories of
transcriptional changes shown in figure 2. Ud=Urtica
dioica, Ru=Ribes uva-crispa
|
Table 1.
Candidate genes involved in a direct response to Urtica and
Ribes. Genes with at least five-fold differential expression
between Urtica and Ribes treatments 17 hours after a
switch to Host 2 compared to controls remaining on Host 1 (i.e.,
UdUd - UdRu or RuRu - RuUd). Gene name and
functional description are given for each gene. Furthermore, names of
orthologs genes in Heliconius melpomene and the corresponding
gene description are given. Gene function was determined based on the
functional annotations of both datasets. Moreover, the regulation of
gene expression on Host 2 after the switch is stated. Each gene was
classified based on the categories of transcriptional changes shown in
figure 2. Note that an upregulation on one host can be interpreted as a
downregulation on the alternative host. Genes in bold were highly
upregulated on the same host also in the earlier study (without a
switch; Celorio-Mancera et al. 2023) . NA = not annotated. Each
gene was classified based on the categories of transcriptional changes
shown in figure 2. Ud=Urtica dioica,
Ru=Ribes uva-crispa
|
Host pair comparisons |
Gene name |
Description |
H. melpomene ortholog
|
Description based on H. melpomene ortholog |
Gene function |
Regulation of gene expression on Host
2 |
category |
UdUd - UdRu
|
g3036 |
chitin binding; involved biological
process described with chitin metabolic process |
HMEL002002-PA |
Peritrophic matrix 1-b precursor |
Chitin
binding,
Gut peritrophic matrix development
|
Upregulation on Ribes
|
3 |
UdUd - UdRu
|
g94 |
Proline dehydrogenase |
HMEL003569-PA |
Sluggish isoform
a-like;
proline dehydrogenase
|
Proline metabolism |
Upregulation on Ribes
|
3 |
UdUd - UdRu
|
g12792 |
Trypsin-like serine protease |
HMEL003683-PA |
Hemolymph proteinase 9 |
Serine protease |
Upregulation
on Ribes
|
3 |
UdUd - UdRu
|
g11908 |
NA |
HMEL004395-PA |
NA |
NA |
Upregulation on Ribes
|
3 |
UdUd - UdRu
|
g13507 |
Glutathione S-transferase,
C-terminal domain |
HMEL006527-PA |
Glutathione s-transferase 1-like |
Detoxification |
Upregulation on Ribes
|
3 |
UdUd - UdRu
|
g1835 |
Zinc finger, C2H2 type, GLIS2 |
HMEL006553-PA |
Zinc finger protein gli1-like |
Transcription factor |
Upregulation on Ribes
|
1 |
UdUd - UdRu
|
g6954 |
Peptide methionine sulfoxide
reductase |
HMEL008564-PA |
Methionine sulfoxide reductase |
Response to
oxidative stress |
Upregulation on Ribes
|
1 |
UdUd - UdRu
|
g18164
g18165
|
NA |
HMEL009345-PA |
Aldo-keto reductase |
Metabolism,
detoxification |
Upregulation on Ribes
|
1 |
UdUd - UdRu
|
g7930 |
Immunoglobulin domain |
HMEL012261-PA |
Lachesin-like |
Neurogenesis |
Upregulation on
Ribes
|
3 |
UdUd - UdRu
|
g500 |
NA |
HMEL014522-PA |
Endonuclease-reverse transcriptase |
DNA repair |
Upregulation on
Ribes
|
3 |
UdUd - UdRu
|
g8589 |
NA |
HMEL015934-PA |
Lipase |
Lipid
catabolism, Phagocytosis |
Upregulation on Ribes
|
3 |
UdUd - UdRu
|
g19077
g19078
|
NA |
HMEL016210-PA |
NA |
NA |
Upregulation on Ribes
|
1 |
UdUd - UdRu
|
g12522
g12526
|
NAD(P)-binding
Rossmann-like domain |
HMEL016306-PA |
Spermine oxidase-like |
Polyamine metabolism |
Upregulation on Ribes
|
1 |
UdUd - UdRu
|
g2848 |
NA |
NA |
NA |
NA |
Upregulation on
Ribes
|
3 |
UdUd - UdRu
|
g11512 |
NA |
NA |
NA |
NA |
Upregulation on
Ribes
|
1 |
UdUd - UdRu
|
g18835 |
NA |
NA |
NA |
NA |
Upregulation on
Ribes
|
1 |
UdUd - UdRu
|
g17488 |
Major Facilitator Superfamily |
HMEL008930-PA |
Sialin-like transporter |
Transmembrane transport,
Sialic acid
transport
|
Downregulation on Ribes
|
3 |
UdUd - UdRu
|
g21009 |
Chorion protein |
HMEL011168-PA |
Chorion class cb protein m5h4-like |
Structural protein |
Downregulation
on Ribes
|
3 |
UdUd - UdRu
|
g3540
g19683
|
metallocarboxypeptidase
activity; involved in biological process described with proteolysis |
HMEL012401-PA |
Carboxypeptidase-like |
Protein metabolism |
Downregulation on Ribes
|
1 |
UdUd - UdRu
|
g15631
g15249
|
NA |
HMEL012909-PA |
Synaptic vesicle glycoprotein-like |
Transmembrane transport |
Downregulation on Ribes
|
1 |
UdUd - UdRu
|
g15247 |
synaptic vesicle |
HMEL012912-PA |
Synaptic vesicle protein 2-like |
Transmembrane
transport |
Downregulation on Ribes
|
3 |
UdUd - UdRu
|
g1204 |
NA |
NA |
NA |
NA |
Downregulation
on Ribes
|
3 |
UdUd - UdRu
|
g15555 |
NA |
NA |
NA |
NA |
Downregulation
on Ribes
|
3 |
RuRu - RuUd
|
g11903 |
Trypsin-like serine protease |
HMEL004401-PA |
serine protease easter-like; Clip domain serine protease
like 4 |
Immune response |
Upregulation on Urtica
|
3 |
RuRu - RuUd
|
g12017 |
NA |
HMEL008841-PA |
NA |
NA |
Upregulation on Urtica
|
3 |
RuRu - RuUd
|
g188 |
N-acetylmuramoyl-L-alanine amidase |
HMEL009426-PA |
peptidoglycan recognition protein-d |
Innate immune
response |
Upregulation on Urtica
|
3 |
RuRu - RuUd
|
g1152 |
NA |
HMEL010472-PA |
transcription
factor hnf-4 homolog |
Involved in gut formation |
Upregulation on
Urtica
|
3 |
RuRu - RuUd
|
g2711 |
Alkaline phosphatase |
HMEL010183-PA |
alkaline phosphatase, tissue-nonspecific isozyme |
Transmembrane
transport |
Upregulation on Urtica
|
3 |
RuRu - RuUd
|
g15249 |
NA |
HMEL012909-PA |
Synaptic vesicle glycoprotein-like |
Transmembrane transport |
Upregulation on Urtica
|
1 |
RuRu - RuUd
|
g7501 |
Gloverin-like protein |
HMEL017163-PA |
Gloverin; antibacterial peptide |
Immune
response, Antimicrobial defense |
Upregulation on Urtica
|
1 |
RuRu - RuUd
|
g19716 |
NA |
HMEL017191-PA |
unclassified
opsin |
NA |
Upregulation on Urtica
|
3 |
RuRu - RuUd
|
g15789 |
NA |
NA |
NA |
NA |
Upregulation on
Urtica
|
3 |
RuRu - RuUd
|
g9519 |
structural molecule activity |
HMEL002160-PA |
NA |
structural integrity of a complex |
Downregulation
on Urtica
|
3 |
RuRu - RuUd
|
g1835 |
Zinc finger, C2H2 type, GLIS2 |
HMEL006553-PA |
Zinc finger protein gli1-like |
Transcription factor |
Downregulation on Urtica
|
1 |
RuRu - RuUd
|
g354 |
Carboxylesterase family, CES5A |
HMEL009236-PA |
esterase fe4-like |
Oxidative stress resistance |
Downregulation on Urtica
|
3 |
RuRu - RuUd
|
g17913 |
NA |
HMEL014531-PA |
NA |
NA |
Downregulation on Urtica
|
3 |
RuRu - RuUd
|
g10799 |
Fungal protease inhibitor |
HMEL015606-PA |
cationic peptide cp8 precursor |
Immune response |
Downregulation on Urtica
|
3 |
RuRu - RuUd
|
g19077
g19078
|
NA |
HMEL016210-PA |
NA |
NA |
Downregulation on Urtica
|
1 |
RuRu - RuUd
|
g3815 |
NA |
NA |
NA |
NA |
Downregulation
on Urtica
|
3 |