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A Potential Antiviral Role for CCR5+CD8+ T Cells in Children with Hepatitis B
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  • Aoxue Tan,
  • Yi He,
  • Yingzhi zhou,
  • Xiaorong Peng,
  • Yunan Chang,
  • Mingli Peng,
  • Hong Ren,
  • Hongmei Xu
Aoxue Tan
Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders
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Yi He
Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders
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Yingzhi zhou
Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders
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Xiaorong Peng
Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders
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Yunan Chang
Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders
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Mingli Peng
The Second Affiliated Hospital of Chongqing Medical University
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Hong Ren
The Second Affiliated Hospital of Chongqing Medical University
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Hongmei Xu
Children's Hospital of Chongqing Medical University Ministry of Education Key Laboratory of Child Development and Disorders

Corresponding Author:xuhongm0095@cqmu.edu.cn

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Abstract

Background: While dysfunctional exhausted CD8+ T cells hamper viral control when children acquire hepatitis B virus (HBV) infection, it’s crucial to recognize that CD8+ T cells have diverse phenotypes and functions. This study explored a subset of CD8+ T cells expressing C - C chemokine receptor type 5 (CCR5) in children with HBV infection. Methods: 36 patients in the immune tolerant (IT) group, 33 patients in the immune active (IA) group, and 55 patients in the combined response (CR) group were enrolled. The frequency, functional molecules and effector functions of the CCR5+CD8+ T cells population in different groups were evaluated. Results: The frequency of CCR5+CD8+ T cells correlated positively with the frequency of CCR5+ CD4+ T cells and patient age, and it correlated negatively with ALT, AST, HBV DNA, HBsAg and lactic dehydrogenase levels. CCR5+CD8+ T cells had higher levels of inhibitory and activated receptors and produced higher levels of IFN-γ, IL-2, and TNF-α than CCR5-CD8+ T cells. Conclusion:CCR5+CD8+T cells were partially exhausted but possessed a stronger antiviral activity than CCR5-CD8+T cells. The identification of this subset increases our understanding of CD8+ T cell functions and serve as a potential immunotherapeutic target for children with HBV infection.
Submitted to Journal of Medical Virology
10 Feb 2024Review(s) Completed, Editorial Evaluation Pending
13 Feb 2024Editorial Decision: Revise Major
01 Apr 20241st Revision Received
03 Apr 2024Submission Checks Completed
03 Apr 2024Assigned to Editor
12 Apr 2024Reviewer(s) Assigned
25 Apr 2024Review(s) Completed, Editorial Evaluation Pending
30 Apr 2024Editorial Decision: Accept