The Weizhou X low-permeability reservoir is an offshore reservoir, with a permeability ranging from 0.58×10 ^-3μm ² to 470.05×10 ^-3μm ², showing strong heterogeneity. In the subsequent water injection development, good results were not always obtained. The main problem was that during the water injection process, the injection pressure increased significantly, resulting in low water injection volume and low water injection efficiency, which could not maintain long-term effective effects on production. Improvement, it is difficult to replenish energy in the formation. Through the analysis of pore-throat structure, water quality compatibility and sensitivity, it is clear that pore-throat blockage is the main reason for low water injection efficiency. Aiming at the present situation that the scaling matter is mainly calcium carbonate, a solution to soil acidification and plugging removal was proposed, and the water injection damage of the actual reservoir was simulated. The indoor acidification experiment was carried out, which showed that the effect of acidification on the transformation of the reservoir was good, and the average rate of transformation is 129.21%. Suggestions are put forward for the effective development of Weizhou X low-permeability reservoirs, the economic benefits of development are improved, and guidance is given for the enhanced injection measures of low-permeability oilfields.