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Annulation cascades of cyclosulfonium salts and alkenes towards sulfur-containing N-heterocycles by visible light/copper catalysis
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  • Jie Ma,
  • Xufeng Li,
  • Yuqing Chen,
  • Yongjia Shi,
  • Xiuyan Song,
  • Jian Lv,
  • Daoshan Yang
Jie Ma
Qingdao University of Science and Technology
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Xufeng Li
Zhejiang Wansheng Co., Ltd.
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Yuqing Chen
Qingdao University of Science and Technology
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Yongjia Shi
Qingdao University of Science and Technology
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Xiuyan Song
Qingdao University of Science and Technology
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Jian Lv
Qingdao University of Science and Technology
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Daoshan Yang
Qingdao University of Science and Technology

Corresponding Author:yangdaoshan@tsinghua.org.cn

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Abstract

Although, great achievements have been made in the synthesis of heterocycles using radical addition/cyclization strategy, developing versatile alkyl radical precursors, especially the non-stabilized ones for this method still remains a huge challenge. Herein, we report an efficient annulation cascade reaction between cyclosulfonium salts and alkenes for the synthesis of sulfur-containing N-heterocycles by visible light/copper catalysis under mild conditions. The C−S bond cleavage/radical cascade reaction delivers a variety of corresponding N-heterocycles containing aryl alkyl thioether motifs with good functional group tolerance. Significantly, the current system could be used for the late-stage functionalization of complex bioactive molecules.
Submitted to Chinese Journal of Chemistry
01 Feb 2024Assigned to Editor
01 Feb 2024Submission Checks Completed
01 Feb 2024Review(s) Completed, Editorial Evaluation Pending
03 Feb 2024Reviewer(s) Assigned
18 Feb 2024Editorial Decision: Revise Minor
07 Mar 2024Submission Checks Completed
07 Mar 2024Assigned to Editor
07 Mar 2024Review(s) Completed, Editorial Evaluation Pending