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Multinational study of allergic sensitization to ten fish species indicates patient-dependent tolerance of specific fish
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  • Tanja Kalic,
  • Annette Kuehn,
  • Martina Aumayr,
  • Joan Bartra,
  • Carsten Bindslev-Jensen,
  • Francoise Morel-Codreanu,
  • Olga Domínguez,
  • Peter Forstenlechner,
  • Wolfgang Hemmer,
  • Sandip Kamath,
  • Agnes Sze Yin Leung,
  • Nicki Leung,
  • Yuri Lifanov,
  • Charlotte Mortz,
  • Mariona Pascal,
  • Robin Ristl,
  • Martin Sørensen,
  • Öykü Üzülmez,
  • Lusine Yeghiazaryan,
  • Gary Wong,
  • Christine Hafner,
  • Heimo Breiteneder
Tanja Kalic
Karl Landsteiner Privatuniversitat fur Gesundheitswissenschaften GmbH
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Annette Kuehn
Luxembourg Institute of Health Department of Infection and Immunity
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Martina Aumayr
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
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Joan Bartra
Hospital Clinic de Barcelona
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Carsten Bindslev-Jensen
Odense Universitetshospital
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Francoise Morel-Codreanu
Centre Hospitalier de Luxembourg Eich
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Olga Domínguez
Hospital Sant Joan de Deu Servei d'Allergia i Immunologia Clinica
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Peter Forstenlechner
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
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Wolfgang Hemmer
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
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Sandip Kamath
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
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Agnes Sze Yin Leung
The Chinese University of Hong Kong School of Life Sciences
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Nicki Leung
The Chinese University of Hong Kong School of Life Sciences
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Yuri Lifanov
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
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Charlotte Mortz
Odense Universitetshospital
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Mariona Pascal
Universitat de Barcelona Facultat de Biologia
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Robin Ristl
Medizinische Universitat Wien Zentrum fur Medizinische Statistik Informatik und Intelligente Systeme
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Martin Sørensen
Universitetssykehuset Nord-Norge Fertilitetspoliklinikken IVF Tromso
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Öykü Üzülmez
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie
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Lusine Yeghiazaryan
Medizinische Universitat Wien Zentrum fur Medizinische Statistik Informatik und Intelligente Systeme
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Gary Wong
The Chinese University of Hong Kong School of Life Sciences
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Christine Hafner
Karl Landsteiner Privatuniversitat fur Gesundheitswissenschaften GmbH
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Heimo Breiteneder
Medizinische Universitat Wien Zentrum fur Pathophysiologie Infektiologie und Immunologie

Corresponding Author:heimo.breiteneder@meduniwien.ac.at

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Abstract

Background: Recent studies indicated that fish-allergic patients may safely consume certain fish species. Multiplex IgE testing facilitates the identification of species tolerated by individual patients. Methods: Sera were collected from 263 fish-allergic patients from Austria, China, Denmark, Luxembourg, Norway and Spain. Specific (s) IgE to parvalbumins (PVs) from 10 fish species along with IgE to 7 raw and 6 heated fish extracts was quantified using a research version of the ALEX 2 assay. IgE-signatures of individual patients and patient groups were analyzed using SPSS and R. Results: sIgE to alpha-PV from ray, a cartilaginous fish, was not detected in 78% of the patients while up to 41% of the patients, depending on their country of origin, tested negative for at least one beta-PV. sIgE values were highest for mackerel and tuna PVs (>10 kUA/L) and significantly lower for cod (4.9 kUA/L) and sole PVs (2.55 kUA/L). 17% of the patients, although negative for PVs, tested positive for the respective fish extracts. Based on the absence of IgE to PVs and extracts, up to 21% of the patients were identified as potentially tolerating one or more bony fish. Up to 90% of the patients tested negative for ray. The probability of negativity to one fish based on negativity to others was calculated. Negativity to tuna and mackerel emerged as a good marker of negativity to additional bony fish. Conclusion: Measuring sIgE to PVs and extracts from evolutionary distant fish species indicates bony and cartilaginous fish species for tolerance-confirming food challenges.
Dec 2022Published in The Journal of Allergy and Clinical Immunology: In Practice volume 10 issue 12 on pages 3284-3292. 10.1016/j.jaip.2022.08.019