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\begin{document}

\title{Risk factors for implantable cardioverter defibrillator in patients with
premature ventricular contractions in Olmstate County}



\author[1]{Shan Hu}%
\author[1]{Beilei Liu}%
\author[2]{Yong-Mei Cha}%
\author[1]{Gang Wu}%
\affil[1]{Wuhan University Renmin Hospital}%
\affil[2]{Mayo Clinic Rochester}%


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  \date{June 13, 2024}


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\begin{abstract}
\textbf{Background:} Premature ventricular contractions (PVCs) are
associated with an increased risk of implanting implantable cardioverter
defibrillator (ICD). Therefore, our study aimed to predict the risk
factors for implantable cardioverter defibrillator in patients with
premature ventricular contractions. \textbf{Methods:} A total of 309
patients (male 57\%, mean age 66.73\selectlanguage{ngerman}±16.12) in Olmstate Countywho had
premature ventricular contractions and received a 24-hour
electrocardiography monitoring were included between January 1994 and
September 2010 at Mayo Clinic, Rochester, Minnesota. All these patients
were continuously followed o Jun 2015. Student's t-test, Chi-square,
univariate and multivariate Logistic regression models were used to
estimate the relationship between the risk factors and the incidence of
implanting implantable cardioverter defibrillator (ICD) in PVCs
patients. Kaplan--Meier curve of survival in PVCs patients with ICD or
free-ICD. \textbf{Results:} The average follow-up time was 9.3±3.9
years, in which 43 (13.9\%) patients died and 24 (7.8\%) patients had
received ICD therapy. Sex, age, pulse pressure, early repolarization
syndrome (ERS), heart rate, PVC coupling interval, QRS duration, left
ventricular ejection fraction (LVEF), left ventricular end-diastolic
dimension (LVEDD) and left ventricular end-systolic dimension (LVESD),
diabetes were significantly associated with the mortality and the
incidence of implanting ICD. Using a multivariate logistic regression
model adjusted for potential confounders, showed that LVEF (OR=0.916,
95\% CI:0.881 to 0.953, p\textless{}0.001) and pulse pressure (OR=1.032,
95\% CI:1.001-1.064, p=0.045) were independent factors for ICD implant
in PVCs patients. Moreover, implantation of ICD may not reduce mortality
in patients with ventricular premature. \textbf{Conclusions:} Increased
pulse pressure was associated a higher incidence of ICD in PVCs
patients, among many electrocardiographic and clinical variables
studied. We also showed that PVs patients with ICD were at high risk of
death, and the great pulse pressure was linked with higher morality in
PVCs patients.%
\end{abstract}\selectlanguage{ngerman}%



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