Point-of-care ultrasonography is a non-invasive, convenient, and reproducible method used in the diagnosis of patients admitted to the intensive care unit. We report a case of acute aortic dissection presenting as acute myocardial infarction and cerebral infarction confirmed through point-of-care ultrasonography. The patient received timely and effective treatment. However, the sensitivity of point-of-care ultrasonography cannot be overestimated, and CTA still needs to be combined.