Background: Pericardial cyst is a common lesion of the mediastinum. Most of them are located outside the pericardial space, such as in the diaphragmatic angle. However, Intrapericardial cyst is exceedingly rare, especially in symptomatic cases, which usually require surgical resection. To the best of our knowledge, this is the first case report on minimally surgery for Intrapericardial cyst. Aim: To Provide a new idea for minimally invasive surgical treatment of intrapericardial cysts. Materials and Methods and Results: A 55-year-old women who has progressive chest pain and palpitations symptomatic and diagnosed with intrapericardial cyst, and her clinical symptoms were significantly alleviated after resected by video-assisted thoracoscopic surgery（VATS）. Conclusion: Video-assisted thoracoscopic surgery which is a feasible surgical method can greatly reduce surgical trauma and accelerate postoperative recovery and can achieve an excellent therapeutic effect.