Objective: Bronchiectasis is a condition characterized by irreversible abnormal dilation and anatomic breakdown of the bronchial tree. In our study we aimed to understand the causes of osteoporosis at molecular levels and to investigatethe usefulness of RANKL and OPG levels as markers in early diagnosis and follow-up of osteoporosis, RANKL inhibitors in the treatment of osteoporosis. Materials and Methods: 30 noncystic fibrosis bronchiectasis patients were diagnosed as osteoporosis with DEXA and applied to the Pediatrics Chest Diseases Department of Meram Medical Faculty of Necmettin Erbakan University between June 2015 and June 2016 were included in our study. BMD values were determined by DEXA and QUS in the patient group and only QUS in the control group. Results: In the patient group 56.6% (n: 17) were male, 43.4% (n: 13) were. There was no statistically significant difference between RANKL, OPG, RANKL / OPG ratios, BALP, OST, NTX values between the patient and control group (p> 0.05). The median serum Ca level was 9.51 (IQC: 0.74) in the patient group and 9.75 (IQC: 0.47) in the control group, there was a statistically significant difference between them (p = 0.003). There was a strong positive correlation between QUS z scores and DEXA z scores in the patient group (p = 0.008). Conclusion: In conclusion, we could not pinpoint the role of RANK / RANKL / OPG in the pathogenesis of osteoporosis in patients with noncystic fibrosis bronchiectasis. However, we think it is appropriate to conduct studies on a wider series in this topic.