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Cryoablation vs. Anti-Arrhythmic drug therapy as a first line treatment in Atrial fibrillation (meta-analysis and systematic review)
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  • Akram EL Remlawi,
  • Kameel El Awar,
  • Ola EL Zein,
  • Marwan Refaat
Akram EL Remlawi
American University of Beirut
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Kameel El Awar
American University of Beirut
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Ola EL Zein
American University of Beirut
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Marwan Refaat
American University of Beirut Medical Center

Corresponding Author:mr48@aub.edu.lb

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Abstract

Intro: Atrial fibrillation (AF) is the most frequently diagnosed arrhythmia in practice. Current guidelines on management of AF suggest that patients should be treated with antiarrhythmic drugs (AAD) as first-line therapy, our meta-analysis aims to assess the benefit of using of Cryoablation as a first line therapy for people with atrial fibrillation. Methods: We conducted an electronic search using Medline, Embase, CINAHL and google scholar along with other clinical trial registries. Results: 2 studies out of 9,244 studies fit our eligibility criteria. A total of 521 subjects were included in both studies and 4 distinct meta-analyses were performed. In terms of recurrence CA was superior to AAD with a RR of 0.6. For serious adverse events CA was also superior to AAD with a RR of 0.66 and for treatment related SAE the results were insignificant. Conclusion: CA proved to be superior in terms of recurrence and adverse effects versus AAD.