Influenza virus developed resistance to the currently class of drugs, which eventually becoming more virulent and cause more mortality and hospitalization. Our study aims to search new candidate drugs from the plant source. We investigated the cytotoxicity of R. stricta euouaes extract and its antiviral activity against influenza virus (A/Puerto Rico/8/34 (H1N1)) using MTT assay. The mode of action of the plant extract was tested using time of addition assay. in silico study was performed including molecular docking, ADME assay and toxicity risk assessment to investigate the best compound to be developed into anti-influenza virus drug. The cytotoxicity concentration 50% of the extract was (CC50: 184.6µg/ml) and the Inhibitory concentration was (CI50: 19.71 µg\ml and SI 9.37. The time of addition assay revealed that, R. stricta extract exerted its activity in the late step of the influenza virus replication cycle. The in silico study demonstrated that some compounds can be subjected to in vitro study. Therefore, isolation and purification of the candidate compounds and testing their antiviral activity are recommended.