Background: Diabetes self-management education is an essential component of caring for the disease, and evidence shows that it can even reduce overall mortality in patients with type 2 diabetes. However, no study was found to compare the effects of these interventions on patients’ quality of life. Therefore, we decided to systematically review the interventions that have been done to promote self-management of type 2 diabetes and their effect on Quality of life. Methods: Twelve databases were searched for systematic reviews without date and language restrictions, the data extracted and the quality of the studies was assessed using the AMSTAR2 checklist. Quality of life was considered as the main outcome of the study and the results of the studies were presented qualitatively. Results: The present study includes the results of 51 systematic review studies in 16 countries over 20 years, covering a wide range of self-management interventions and quality-of-life assessment tools. The highest number of studies was presented in the form of telemedicine. The most effective interventions on patients’ quality of life were self-management interventions that included the patient’s social network (family, friends, etc.) and interventions that provided individual strategies for managing the individual’s illness. Conclusion: Self-management interventions in diabetes cover a wide range, and their effects on quality of life are a matter of debate.