Talaromyces marneffei (T. marneffei) is an opportunistic pathogen that infects immunodeficient and immunocompromised patients. We presented a pediatric patient with a diagnosis of T. marneffei infection who were followed up in the Guangzhou Women and Children’s Medical Center. The child was a 5-year-old girl with persistent coughed and gasped for two months, and she was confirmed with T. marneffei infection by bronchoalveolar lavage fluid(BALF) culture and high-throughput sequencing technology. Human immunodeficiency viru(HIV) was negative according to a serum-specific antibody test. She was treated with amphotericin B and itraconazole as antifungal agents with good clinical response. At the follow up, the high resolution computed tomography (HRCT) showed mosaic sign in the whole lung field with a diagnosis of post-infectious bronchiolitis obliterans (PIBO) as the sequela. She has a mutated COPA gene with uncertain pathogenic potential by the whole-exome sequencing. This is the first report of PIBO sequelae from T. marneffei infection in child with non-HIV infection and she was identified with a mutation in COPA gene.