Rationale, aims and objectives: The Post Stroke Checklist (PSC) is not capable of enforcing post-stroke follow-up and needs to be further optimized. The objective of this study is to describe an evidence-based optimization of the PSC (the Chinese version of the PSC, C-PSC), and evaluate its feasibility and usability in clinical practice. Method: Participants were consecutively recruited from 13 departments in a specialized hospital. Data were collected from April 2021 to May 2021. The trained clinicians contacted stroke survivors by telephone calls at six months since diagnosis. A satisfaction questionnaire was sent to the participant whilst clinicians completed a satisfaction questionnaire and the Pragmatic Face and Content Validity Test (PRAC-Test). Then, a debriefing meeting was held. Quantitative and qualitative data were both collected. Results: A total of 167 individuals consented to take part in the study.113 participants completed the assessment at six months and three were excluded due to missing data. The C-PSC identified a wide range of unmet needs related to stroke and at least one need was reported in 76.4% of individuals. The average time taken to administer the C-PSC was 8 mins. The minimum content validity index for each item exceeded 0.78 and the average was 0.98 with a scale-content validity index greater than 0.90. Satisfaction ratings were high for individuals (8.5/10) and clinicians (9.6/10). The average rating measured by PRAC-Test was higher than 9.0/10 except for two items. Totally 31 further screenings were conducted and 33 appropriate referrals were accomplished. Several areas for improvement were identified and revised. Conclusions: The C-PSC is a feasible and useful measure in enforcing follow-up caring and promising to be an approach in standardizing post-stroke follow-up practices.