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Rhabdomyolysis Secondary to Vildagliptin Overdose in a Suicidal Attempt: A Case Report
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  • Nan Guo,
  • Bing Han,
  • Xiaofang Fan,
  • Zhen Feng,
  • Zhijia Tang
Nan Guo
Minhang Hospital & Department of Clinical Pharmacy at School of Pharmacy, Fudan University
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Bing Han
Minhang Hospital & Department of Clinical Pharmacy at School of Pharmacy, Fudan University
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Xiaofang Fan
Fudan University Minhang Hospital
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Zhen Feng
Fudan University School of Pharmacy
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Zhijia Tang
Fudan University School of Pharmacy

Corresponding Author:zjtang@fudan.edu.cn

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Abstract

Rhabdomyolysis is a life-threatening adverse drug reaction that is seldom reported in DPP-4 inhibitors. Here we present a case in which a 58-year-old female suffered from severe swelling and pain in bilateral lower limbs and oliguria for 1 week after a suicidal attempt that she took vildagliptin 1,400 mg and insulin aspart 60 IU. She was diagnosed with rhabdomyolysis, diabetic ketoacidosis (DKA), urinary tract infection (UTI) and drug-induced liver injury (DILI). After 20 days of hospitalization, significant improvement had occurred in almost all laboratory results, and the patient was discharged without sequelae. This is a rare case suggesting that severe adverse events (SAEs), such as rhabdomyolysis, may occur in relatively safe oral hypoglycemic drugs.