Figure titles and legends
Figure 1. Casadevall and Pirofski’s damage-response framework of microbial pathogenesis. The y -axis denotes host damage as a function of the host response. Damage can occur throughout the host response, which is represented by a continuum from ‘weak’ to ‘strong’. Therapeutic intervention can shift the curve towards benefiting the host, as denoted by the arrow.
Figure 2. Pharmacological profile of azithromycin during COVID-19 pneumonia pathogenesis. Establishment of pan-pathogen antimicrobials facilitates discovery of conserved pharmacological properties against multiple pathogen types. For example, lysosomotropicity has emerged as a desideratum for both antimalarial and antiviral therapeutics. Drug-disease interactions of pan-pathogen antimicrobials can further provide mechanistic insights into the general nature of infection. In so doing, pan-pathogen antimicrobials can drive the unification of the microbiological and immunological disciplines, first envisioned by Casadevall and Pirofski.