Objective:To analyze the clinical characteristics of CRP, LDH, ESR, D-Dimer, Neutrophils (%), Lymphocytes (%) and lung consolidation in refractory Mycoplasma pneumoniae pneumonia (RMPP), and explore their prediction results for RMPP. Methods：Systematic search was conducted in PubMed, Embase, Cochrane Library, Web of Science, CNKI, Wangfang and Cqvip, and the date was set until February 23, 2021. For the continuous variables, Weighted Mean Difference (WMD) with 95% CI or Standard Mean Difference (SMD) with 95% CI was adopted to evaluate CRP, LDH, ESR, D-Dimer, Neutrophils (%), Lymphocytes (%) and the correlation between lung consolidation and RMPP. Results: 20 studies including 5289 patients were included in the analysis, and the results showed: the CRP of the RMPP group [WMD (95%CI): 17.529 (10.514, 24.544), P＜0.001], LDH [WMD (95%CI): 114.884 (51.435, 178.333), P＜0.001], Neutrophils (%) [WMD (95%CI): 17.271 (0.309, 14.233), P=0.041], Neutrophils (×109/L) [WMD (95%CI): 1.249 (0.307, 2.191), P=0.009] was higher than that of the NRMPP group; the risk of lung consolidation in the RMPP group [OR(95%CI): 14.286 (4.523, 45.120), P＜0.001] was higher than that in the NRMPP group; and there was no difference in ESR [WMD (95%CI): 8.111 (-1.339, 17.562), P=0.093], D-Dimer [SMD (95%CI): 0.920 (-0.247, 2.086) p=0.122], Lymphocytes (%) WMD (95%CI): -6.379 (-13.922, 1.163), P=0.097] between the two groups. Conclusions: The available evidence indicates that CRP, LDH, Neutrophils (%), Neutrophils (×109/L) and lung consolidation are risk factors for RMPP.