Background Background: Crocin is a natural ingredient of saffron (Crocus sativus L.) flower. Crocin has been examined for its potential to treat various eye diseases such as glaucoma, macular dystrophies, diabetic retinopathy, and age-related macular degeneration. Methods: This review briefly discusses the role of crocin in different eye diseases. The underlying pathophysiological pathways involved in the effect of crocin on ophthalmologic diseases are also reviewed. Results: Preclinical evidence shows the cytoprotective, antioxidative, anti-inflammatory, and blood flow enhancing effects of crocin in retinal tissue. Crocin also affects the retinal pathologies through activation of PI3K/Akt and inhibition of NF-κB signaling pathways. Clinical evidence suggests that crocin improves outcomes in patients with retinal degenerations, retinal dystrophies, and glaucoma. Conclusion: Crocin can be used as a potential vision supplement in healthy population and patients with eye diseases.