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Bioprosthesis in aortic valve replacement. Long-term inflammatory response and functionality.
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  • Huitzilihuitl Saucedo-Orozco,
  • Jesus Vargas-Barron,
  • Ricardo Márquez-Velasco,
  • Karla Susana Martinez-Zavala,
  • Valentin Jimenez-Rojas,
  • Sergio Andres Críales-Vera,
  • José Antonio Arias-Godinez,
  • Veronica Guarner-Lans,
  • Israel Perez-Torres,
  • Gabriela Melendez-Ramirez,
  • Efrain Sanchez-Perez,
  • Maria Elena Soto
Huitzilihuitl Saucedo-Orozco
Instituto Nacional de Cardiologia Ignacio Chavez
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Jesus Vargas-Barron
Instituto Nacional de Cardiologia Ignacio Chavez
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Ricardo Márquez-Velasco
Instituto Nacional de Cardiologia Ignacio Chavez
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Karla Susana Martinez-Zavala
Metropolitan Autonomous University
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Valentin Jimenez-Rojas
Instituto Nacional de Cardiologia Ignacio Chavez
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Sergio Andres Críales-Vera
Instituto Nacional de Cardiologia Ignacio Chavez
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José Antonio Arias-Godinez
Instituto Nacional de Cardiologia Ignacio Chavez
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Veronica Guarner-Lans
Instituto Nacional de Cardiologia Ignacio Chavez
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Israel Perez-Torres
Instituto Nacional de Cardiologia Ignacio Chavez
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Gabriela Melendez-Ramirez
Instituto Nacional de Cardiologia Ignacio Chavez
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Efrain Sanchez-Perez
Instituto Nacional de Cardiologia Ignacio Chavez
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Maria Elena Soto
Instituto Nacional de Cardiologia Ignacio Chavez

Corresponding Author:mesoto50@hotmail.com

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Abstract

Abstract Background. The evaluation of long-term inflammatory response and function in postoperative patients with aortic valve replacement (AVR) deserves special analysis because it is important to try to prevent reoperation and improve durability and functionality of the prostheses. Methods In this study we included a cohort of patients with aortic valve damage treated by AVR with mechanical prosthesis, bioprosthesis and we included a control group. Results. We found that IL-4 and OPN levels were higher in patients with mechanical vs. biological prostheses (p = 0.01 and p = 0.04 respectively), OPG levels were decreased (p = 0.01), women had lower levels of ET-1 and IL-6, (p = 0.02) (p = 0.04) respectively. Patients older than 60 years had decreased levels of IL-1ß p <0.001) and a higher concentration of IL-4 p < 0.05). IL-1ß, OPG and TNFα were higher in patients with less than 5 years of evolution versus more than 10 years (p = 0.004, p = 0.02 and p = 0.03 respectively). Factors such as age, gender, prosthetic, and elevated IL-1B and ET-1 levels are associated with valve dysfunction prosthetic. These results indicate that the inflammatory involvement present prior to valve replacement may be perpetuated by various factors in the long term. Conclusions The findings provide us with the opportunity to effectively treat patients with AVR in the postoperative period, which could prolong the functionality of the bioprostheses.