integrative and complementary health practices in differents forms. The evidence map was based on the 3iE evidence searched in the databases: LILACS, PubMed, EMBASE and Cochrane Library, seeking systematic and narrative reviews, analyzed in an excel characterization spreadsheet.The circles located at the intersections between the interventions and the outcomes represent the identified studies. The color of the circles represents the confidence level. In the period from October 2019 to January 2020, fifteen studies were found, five of which were systematic reviews and ten narrative reviews, published between 2006 and 2019, with different levels of confidence. The highlighted intervention was oral ozone therapy as a bacterial colony reduction and decontamination agent, with emphasis on topical oxygen-ozone gas mixtures, topical ozonized water. Oral ozone therapy can bring benefits to clinical practice and patients.