Baeyer–Villiger monooxygenases (BVMOs) can be used for the biosynthesis of ε-Caprolactone by oxidizing cyclohexanone. However, the external supply of co-substrate O2 and redox cofactor NADPH is uneconomical. Thereby, photosynthesis, which can synthesis O2 and NADPH, can be exploited and integrated with oxygenase-based whole-cell biocatalysis.