Introduction: Although most children experience minor symptoms from SARS-CoV-2 infection, some develop complications including MIS-C. Neuroblastoma patients may be at higher-risk of infection. We hypothesized that ACE2, CD147, PPIA and PPIB are poor-prognosis and SARS-CoV-2 infection biomarkers in neuroblastoma. Results: In-depth gene-expression-dataset statistical analysis showed ACE2, CD147, PPIA and PPIB high-expression significantly associated with poor-prognosis neuroblastomas with amplified MYCN, unfavourable-tumors and patients older than 18 months of age. Low-expression was associated with the NTRK1-PTPN6-TP53 module, a good-prognostic marker. Conclusion: ACE2, CD147, PPIA and PPIB high expression is associated with poor-prognosis neuroblastomas. These patients may be at higher-risk of SARS-CoV-2 infection.