The synthesis of vanillin-chitosan Schiff base chelating zinc complex
and its application in vitro sustained release
Abstract
Zinc is an essential element for animals, while zinc salt cannot be
absorbed effectively. In this work, a sustained release
vanillin-chitosan Schiff base (VCSB) zinc complex additives (VCSB-Zn2+)
was prepared and a new in vitro sustained release system suited for this
complex was effectively constructed. The structure of VCSB and VCSB-Zn2+
were characterized by FT-IR, 1H NMR, TGA, XPS and SEM. VCSB exhibited a
more rapid End-point and higher capacity of chelating Zn2+ than
chitosan, and it was also closely related to the content of -C=N.
Furthermore, VCSB-Zn2+ showed excellent sustained release ability at
simulated gastric fluid (SGF) because of the acid slow-dissolving
ability. And the L-cysteine at simulated intestinal fluid (SIF) absorbed
Zn2+. Additionally, the sustained release curves followed first-order
and Korsmeyer-Peppas models, which described Zn2+ sustained release
cause by the dissolution of VCSB-Zn2+ and Fick diffusion. Therefore,
VCSB-Zn2+ is facilitating the application and promotion of zinc
additives.