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Analysis of Clinical Characteristics and Therapeutic Effects in Children with Non-High Risk Neuroblastoma with Spinal Canal Involvement
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  • Cheng Huang,
  • yan su,
  • Chenghao CHEN,
  • Wen Zhao,
  • Xisi Wang,
  • Tong Yu,
  • Qi Zeng,
  • Ming Ge,
  • Xin NI,
  • Xiaoli Ma
Cheng Huang
Beijing Children's Hospital
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yan su
Beijing Children's Hospital
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Chenghao CHEN
Beijing Children’s Hospital
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Wen Zhao
Beijing Children’s Hospital
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Xisi Wang
Beijing Children’s Hospital
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Tong Yu
Beijing Children's Hospital
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Qi Zeng
Capital Medical University
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Ming Ge
Neurosurgery Department, Beijing Children’s Hospital, Capital Medical University
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Xin NI
Beijing Children's Hospital Capital Medical University
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Xiaoli Ma
Beijing Children's Hospital

Corresponding Author:mxl1123@vip.sina.com

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Abstract

Objectives: Summarized the clinical characteristics of non-high risk neuroblastoma with spinal canal involvement. Patients and Methods: Retrospective, single center cohort study of non-high risk patients treated for NB (from March first 2007 to June 30th 2019) with intraspinal extension. We used the Kaplan-Meier curve to analyze and describe the prognosis. All patients followed up to April 30th, 2020. Results: 46 patients were included among the 371 patients. Median age was 13 months, median course of disease was 1 month and median follow up time was 39.5 months. The most prevalent initial symptoms were neurological motor and sensory deficit. The primary sites of the patients were posterior mediastinum. There were 19 patients divided in low risk group and others were in middle risk group. None patient died during the follow up time and 2 patients with progression of the primary disease. 24 cases received neurosurgical intervention, 18 patients’ muscle strength can recover gradually. 8 patients who with sphincter dysfunction received laminectomy and all patients recovered normal. There was an obvious improvement for pain of nerve root in the 17 patients. 14 patients with scoliosis before the laminectomy and the operation didn’t cause an aggravation of the condition. Conclusion: There was a short course and young age at diagnosis to the patients. The primary site usually located in posterior mediastinum. The highest prevalence of initial symptom was muscle strength abnormal. Neurological surgery combined with chemotherapy may relieve the symptoms of spinal canal compression effectively, and improve the quality of life.