Persistence of Fatigue among COVID-19 Survivors in Bangladesh: A
Prospective Cohort Study
Abstract
Background: A limited number of studies have exclusively
assessed fatigue among post-COVID patients. Our study aimed to assess
the persistence and associations of fatigue among COVID-19 survivors
after two months of recovery from their primary illness.
Method: During hospital admission from August to September,
2020, a total of 373 patients were diagnosed to be suffering from
fatigue using Chalder fatigue scale. After obtaining informed written
consent, patients were followed up two months later over telephone. A
total of 332 participants participated in the interview (36 patients
could not be traced and another 5 patient died within two months).
Patients were asked to categorize their present fatigue condition based
on a simplified questionnaire developed for telephone interview.
Result: Among study participants, 62.9% (n=207) were found to
be still suffering from fatigue two months after their hospital
discharge. A significant association of fatigue was found with age
(p=0.000), hypertension (RR: 1.51; CI: 1.15-1.99; p=0.002), diabetes
mellitus (RR: 1.45; CI: 1.08-1.95; p=0.010), ischemic heart disease (RR:
2.04; CI: 1.15-3.64; p=0.011), on admission SpO2 (p=0.000), on admission
serum ferritin (p=0.000), d-dimer (p=0.000), CRP (p=0.000), and Hb%
(p=0.019). Binary logistic regression model revealed significant
association of age and on-admission SpO2 with persistence of fatigue.
Conclusion: Fatigue is a highly prevalent symptom among the
COVID-19 survivors with significant association between fatigue and
patients clinical and laboratory markers.