Fisetin (3, 3′, 4′, 7-tetrahydroxyflavone) belongs to class of flavonoids which is abundant in several fruits and vegetables that we consume daily. Fisetin has manifested several health benefits in preclinical models of neurodegenerative diseases: Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, amyotrophic lateral sclerosis, stroke (both ischemic and hemorrhagic), traumatic brain injury and age-associated changes (physiological and pathological). The main aim of this present paper is to evaluate the role of fisetin in treating several neurological diseases which is attributed to its simultaneous targeting of various molecular pathways. This review provides a comprehensive mechanistic pathway’s pertaining to fisetin role in treating several neurological and neurodegenerative diseases.