Objective: The aim of this clinical trial was to compare the incidence of pain and alveolar osteitis following the administration of a wound-dressing material after the extraction of maxillary premolar teeth. Material and methods: A total of 112 maxillary premolar teeth (right and left) in 56 patients were extracted simultaneously. Patients were randomly divided into two groups: a cotton/gauze pack was applied in the control group and a wound dressing material was applied in the experimental group. Incidence of pain (+/-) and alveolar osteitis (+/-) were recorded after three days. Chi-square test and multiple logistic regression analysis were used for the statistical analysis (p<0.05). Results: The final analysis included 51 patients and 102 teeth. A pain was reported by 44 patients (86.27%) at 88 sockets (86.27%) and alveolar osteitis was detected in 8 sockets (7.84%) of 8 patients (15.68%). A positive pain score was significantly associated with the sockets in the control group (Odds ratio [OR] = 1.828, 95% CI = 1.212-3.66, p=0.18), smoking (OR = 1.214, 95% CI = 1.101-3.25, p=0.012) and insufficient oral hygiene (OR = 1.154, 95% CI = 1.011-3.11, p=0.014). All the sockets with alveolar osteitis (n=8) were in the control group. Conclusion: The wound dressing material used in this study might alleviate the pain experienced after the extraction of maxillary premolar teeth.