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To Treat or Not to Treat? Facing Spontaneous Remission of a Neonatal Malignant Mesenchymal Spindle-Cell Neoplasia
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  • Francesco Venturelli,
  • Micol Babini,
  • Francesco Toni,
  • Mino Zucchelli,
  • Marcello Stella,
  • Alberto Righi,
  • Fraia Melchionda,
  • Andrea Pession
Francesco Venturelli
University of Ferrara
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Micol Babini
IRCCS Istituto Delle Scienze Neurologiche di Bologna
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Francesco Toni
IRCCS Istituto Delle Scienze Neurologiche di Bologna
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Mino Zucchelli
IRCCS Istituto Delle Scienze Neurologiche di Bologna
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Marcello Stella
AUSL della Romagna
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Alberto Righi
IRCCS Istituto Ortopedico Rizzoli, Bologna, Italy
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Fraia Melchionda
IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S Orsola-Malpighi

Corresponding Author:fraia.melchionda@aosp.bo.it

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Andrea Pession
IRCCS Azienda Ospedaliero-Universitaria di Bologna Policlinico S Orsola-Malpighi
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Abstract

We report a case of malignant mesenchymal spindle-cell neoplasia of the skull, diagnosed in a female newborn at 13 days of age by biopsy and subtotal resection. Considering the good clinical condition, the age, tumor histology and the risks associated with surgery and chemotherapy, we proposed a “wait and see” approach with a close radiologic monitoring of the tumor lesion. Surprisingly the tumor showed spontaneous regression both at MRI and ultrasound evaluations. To date, after 12 months of observation, MRI showed sustained remission: the infant recovered from surgery and maintains good clinical condition while follow-up is ongoing.