Until now, there are no parameter available for guiding us the proper test scheme for COVID-19 patients during hospitalization so that the physicians will learn their SARS-CoV-2 nucleic acid test results turning negative timely. This study aims to explore feasible parameters to fulfill above requirements. We collected clinical data from 69 patients (31 SARS-CoV-2 positive pneumonia, 38 SARS-CoV-2 negative pneumonia) in Xiangyang Central Hospital (Xiangyang, China) from Feb 12 to Feb 18, 2020 in this study. The general and laboratory data between two groups were compared and discrepant parameters were used to assess the correlation with viral nucleic acid test positive diagnosis. The sensitivity of these parameters to clinical treatment and their correlation with the nucleic acid Ct value were also analyzed. WBC, LYM% and PLT decreased, while CRP and Hb increased significantly in SARS-CoV-2 positive patients compared to those in common pneumonia patients. LYM%, Hb and WBC had a good predictive ability to distinguish the nucleic acid positive from negative pneumonia. The dynamics of WBC, LYM%, Hb and CRP in nucleic acid positive patients were more sensitive to clinical treatment and gradually returned to normal level. Only LYM% had a significant correlation with Ct value. LYM% dynamics was sensitive to clinical treatment, and significantly correlated with Ct value, and might be feasible parameter to estimate the time for SARS-CoV-2 nucleic acid test results turning negative.