We faced a challenge to save the life of a patient with severe SARS-CoV2 infection. We applied different treatment strategies to cope with viral as well as opportunistic infections. Luckily, we were able to save the life of the patient and then we followed him up for more than 8 months. Patient had weakness, breathing problem along with psychiatric disturbance in post hospitalization period. Eight months later patient had vaccine for COVID-19 which showed a temporary side effects on him. This study can help front line health workers and clinician to save lives of the COVID-19 patients.