Transarterial radioembolization (TARE) with Yttrium-90- microspheres is a well-tolerated and efficient treatment option in adult patients with unresectable primary and secondary liver malignancies. However, the use of TARE has been reported in limited pediatric cases. We present a twelve-year-old male with metastatic unresectable fibrolamellar hepatocellular carcinoma who received multidisciplinary treatments including chemotherapy, TARE, and transarterial chemoembolization with remarkable regression of the hepatic lesions. The patient is alive with the disease and a good quality of life for 33 months since diagnosis.