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COVID-19- induced Granulomatosis with Polyangiitis:a Case Report and Literature Review
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  • Rong Jiang,
  • Haibo Zhou,
  • Long Wen,
  • Xianglong Kong,
  • Zhiguo Zhou
Rong Jiang
First Hospital of Changsha
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Haibo Zhou
First Hospital of Changsha
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Long Wen
First Hospital of Changsha
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Xianglong Kong
First Hospital of Changsha
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Zhiguo Zhou
First Hospital of Changsha

Corresponding Author:zhouzhiguo1217@163.com

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Abstract

Objective To report a case of Granulomatosis with Polyangiitis (GPA)with Diffuse alveolar hemorrhage(DAH)that developed following Coronavirus disease 2019 (COVID-19) in an adolescent boy, and perform a literature review to better understand this disorder.Methods Retrospectively analyze the data of a case of GPA following COVID-19 infection, to summarize the clinical characteristics of GPA following COVID-19 infection by searching the database (PubMed,Wanfang Data,CNKI) and comprehensively analyze the literature results. Results 9 cases were reported,combined with our case,there were 10 cases of GPA following COVID-19 infection,including 4 males and 6 females,with an average age of(40.6±18.6)years,and the time interval between COVID-19 and diagnosis of GPA ranged from 1 day to 3 months for all 10 cases. The rate of mortality was 10.0%(1/10).Commonly seen clinical manifestations were cough(70.0%),dyspnea(50.0%),and Arthralgia/Myalgia(40.0%). CT scans showed ground-glass opacities,multifocal pulmonary nodules.Of all these patients, c-ANCA and PR3-antibody positivity were found .Conclusion COVID-19 pneumonia and COVID-19- induced new-onset GPA share many clinical and radiological features, making it challenging for clinicians to distinguish between the two. Our study also provided some clues about the diagnostic challenge of GPA induced by COVID-19.
13 Sep 2023Submitted to Immunity, Inflammation and Disease
20 Sep 2023Submission Checks Completed
20 Sep 2023Assigned to Editor
20 Sep 2023Review(s) Completed, Editorial Evaluation Pending
25 Sep 2023Reviewer(s) Assigned
18 Feb 20241st Revision Received
21 Feb 2024Review(s) Completed, Editorial Evaluation Pending
21 Feb 2024Reviewer(s) Assigned
12 Apr 2024Editorial Decision: Revise Major
17 May 2024Submission Checks Completed
17 May 2024Assigned to Editor
17 May 2024Review(s) Completed, Editorial Evaluation Pending
17 May 2024Reviewer(s) Assigned
30 Jul 20243rd Revision Received
09 Aug 2024Submission Checks Completed
09 Aug 2024Assigned to Editor
09 Aug 2024Review(s) Completed, Editorial Evaluation Pending
09 Aug 2024Reviewer(s) Assigned
17 Aug 2024Editorial Decision: Accept