Indeterminate cell histiocytosis (ICH) is a rare histiocytic proliferative disease with unknown etigo, which shared immunophenotypic features of Langerhans cell and macrophages. ICH cells express CD1a, S-100, and CD68 whereas langerin (CD207) is negative. This study presents a case of a 75 -year-old man with varying sizes of some scattered annular erythema over his chest, abdomen, limbs and 4 bullous on the thigh for 1.5months. He had about 9 month’s history of esophageal cancer and treated with the radical radiotherapy treatment. Histopathologic examination of his abdomen demonstrated accumulation of mononuclear cells in the epidermis, infiltration of eosinophils and lymphocytes in the dermal superficial layer. The histology of the blister reported the formation of old subepidermal blister, slurry and eosinophils in the blister as well as infiltration of eosinophils and lymphocytes in the dermal superficial layer. Results of immunohistochemistry identified positive for CD1a, S-100 and CD68 in epidermal cells and dermal cells aggregation but negative for CD207. However, the blisters and bullous were found over the lower limbs after 38 days. A diagnosis of bullous pemphigoid (BP) was arrived at according to the examination of histopathology and direct immunofluorescent. Therefore, that esophageal carcinoma, ICH, and BP lied in a single patient, was found to be a rare case that deserved our considering of the possible mechanism.