FRP and MP made substantial contributions to the acquisition of data and analysis and interpretation of data and gave final approval for the version to be published. IB played a major role in the writing and design of the manuscript. CC, FM and FS analyzed and interpreted the immunological, pneumological and gastrointestinal data of the patient, respectively. MCG performed the histological examination of the liver. SC, AG and CC revised the manuscript critically for important intellectual content. All authors have read and approved the final manuscript, agree to be accountable for all aspects of the work, and will ensure that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.