Animals
Female BALB/c mice (6-8 weeks), male and female C57BL/6 mice (8 weeks) were purchased from Beijing Huafukang Biotechnology Co., Ltd. The animals were kept in a specific pathogen-free environment with controlled conditions, including a 12-hour light/dark cycle, 22 ± 1℃ temperature, and 55 ± 5% relative humidity. All experiments were performed according to the National Institutes of Health Guide for Care and Use of Laboratory Animals and were approved by the Bioethics Committee of the Shanghai Institute of Materia Medica (IACUC Protocol #2022-06-ZJP-169; #2022-06-ZJP-177).