Atrial Lesion Sets
Lesion sets were created in the RA and LA in all animals. A posterior line was created from the superior vena cava (SVC) to the inferior vena cava (IVC) using 10mm center-to-center interlesion spacing. Similarly, PVI was performed around the inferior common pulmonary vein. Lesion sets were assigned to one of the 3 CTC cohorts prior to treatment. For LTC and HTC cohorts, all lesions were assigned LTC or HTC, respectively. For the NTC cohort (acute intercaval only), the beginning of an intercaval line was started with HTC, followed by 1-2 applications with NTC (using ICE to confirm close proximity to tissue and targeting LI response <10Ω), and the remainder completed with HTC. EAM and pacing maneuvers were used to assess acute block across intercaval lines and isolation of pulmonary veins. In chronic animals, remapping was performed at 30 days to confirm durability of all lesion sets.