IL-10-modulated dendritic cells from birch pollen- and hazelnut-allergic patients facilitate Treg-mediated allergen-specific and cross-reactive tolerance
Short title: Treg induced allergen specific- and cross-tolerance
Patricia Vanessa Heinl PhD 1, Edith Graulich1, Benno Weigmann PhD 2, Andrea Wangorsch PhD 3, Robert Ose MSc 4*, Iris Bellinghausen PhD 4, Stephan Scheurer PhD3, Stefan Vieths PhD 3, Joachim Saloga MD 4, Kerstin Steinbrink MD 1, 5
1 University Medical Center of the Johannes Gutenberg-University, Department of Dermatology, Division for Experimental and Translational Research, 55131 Mainz, Germany
2 University Hospital Erlangen, University Erlangen-Nürnberg, Department of Internal Medicine, 91054 Erlangen, Germany
3 Paul-Ehrlich-Institute, Molecular Allergology, 63225 Langen, Germany4 University Medical Center of the Johannes Gutenberg-University, Department of Dermatology, 55131 Mainz, Germany
5 University Hospital Münster, University of Münster, Department of Dermatology, Münster, Germany
*The author died prior to submission of this paper. This is one of his last works.
Funding: This work was funded by the German Research Foundation (STE 791/9-1, TR156/C05-246807620, SFB1009/B11-194468054, SFB1066/B06-213555243, SFB1450/C06-431460824 (all to KS).
Corresponding Author: Kerstin Steinbrink, MD, University Hospital Münster, University of Münster, Von-Esmarch-Strasse 58, 48149 Münster, Germany. Tel: +49 (0)251 / 83-56504, Fax: +49 (0)251 / 83-56522, E-mail: kerstin.steinbrink@ukmuenster.de