Objective The purpose of this research was to summarize what is currently known about the role of microRNAs in breast cancer and their possible clinical use based on articles published in peer-reviewed publications up to March 2014. Results MicroRNAs (miRNAs) are a kind of tiny RNA that typically range in length from 21 to 25 nucleotides. It is already common knowledge that microRNAs (miRNAs) play a crucial role in almost every cellular activity in the body, from development to tumorigenesis. MiRNAs in the bloodstream have been demonstrated to be appealing, readily detectable tumor biomarkers in a number of investigations. Breast cancer is among the most frequent forms of the disease. Different subtypes have been shown to have varying therapeutic responses, metastatic potential, and medication resistance in clinical trials. MicroRNAs may be useful in several aspects of breast cancer care, including diagnosis, prognosis, and treatment. Conclusion To choose the most appropriate treatment for each patient, molecular understanding is essential. MicroRNAs have promising use in cancer treatment.