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Infliximab-induced depression and Suicidal behaviour: a serious adverse event to consider
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  • Maissa Thabet,
  • Wissal Ben Yahia,
  • Neila Fathallah,
  • Ahmed Guiga,
  • amira atig,
  • bouraoui ouni,
  • Neirouz Ghannouchi
Maissa Thabet
University of Sousse

Corresponding Author:maissa.thabet22@gmail.com

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Wissal Ben Yahia
University of Sousse
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Neila Fathallah
University of Sousse
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Ahmed Guiga
University of Sousse
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amira atig
University of Sousse
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bouraoui ouni
Medecine university
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Neirouz Ghannouchi
University of Sousse
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Abstract

Infliximab (INF) is a biological widely used in the treatment of various auto-immune diseases including Behçet’s disease. INF and other pro-inflammatory cytokines, has been retained in some cases as a factor in the pathogenesis of various neuropsychiatric conditions. Herein we present the case of an adult man with Behçet’s disease (BD) who developed acute depression leading to suicide after the fourth infusion of infliximab. The patient did not experience disabling depressive syndrome, or suicidal thoughts before. He has never made a prior suicide attempt. He denied any previous episodes of mania or psychosis or a history of trauma. Our patient received a serotonin reuptake inhibitor with a good response which allowed us to maintain infliximab therapy.