Materials
Bardoxolone methyl (CDDO-Me; Figure 1a) was purchased from Shanghai Heat-Biochem, Inc. (Shanghai, China), and methyl cellulose was purchased from Fujifilm Wako Pure Chemical Corporation (Osaka, Japan). A choline-deficient, L-amino acid-defined, high-fat diet (CDAHFD) consisting of 60 kcal% from fat was obtained from Research Diets, Inc. (New Brunswick, NJ).