OBJECTIVE: This wellness program sought to identify the prevalence of burnout in a pediatric hematology/oncology/blood and marrow transplantation (BMT) center and to tailor workplace wellness initiatives to support staff. METHODS: Providers and staff from a pediatric hematology/oncology/BMT center were invited to complete an anonymous survey that included items from the Maslach Burnout Inventory for Medical Personnel (MBI-MP) and author-developed questions to assess burnout and helpfulness of program initiatives. Analyses included descriptive and inferential statistics. RESULTS: Just over half of respondents endorsed high risk of burnout. Advanced Practice Providers (APPs), Registered Nurses (RN)/Care Partners (CP), and the Oncology and Multiple specialties (individuals serving multiple specialties [i.e., oncology and BMT]) had the largest proportions of individuals at high risk of burnout. Inpatient nurses and those who have worked in the division for 1-5 years endorsed greater risk of burnout compared to their counterparts. Most respondents reported all initiatives were somewhat to very helpful, with initiatives aimed at bereavement support rated as most helpful. CONCLUSIONS: Our wellness program continues to refine the initiatives offered to align with our purpose of increasing engagement, reducing burnout, and improving staff retention. While the benefits of programming targeting individual level drivers of burnout should be highlighted, the critical state of burnout requires leadership support and engagement in wellness efforts to advance wellness culture in the medical field beyond the limits of individual level interventions alone.