Figure 9: Transcriptomic and metabolomic analysis jointly
unveiled the mechanism of combination drug therapy for silicosis. (A)Heatmap of DEGs between Si group (n=6) and COM group (n=5), COM
indicates low dose of combination drug therapy. (B) Volcano
plot of DEGs between Si group and COM group. (C) KEGG pathway
analysis of DEGs between Si group and COM group. (D) Venn
diagram showing the overlapping pathways among four comparisons,
including PBS vs Si, Si vs PFD, Si vs BIBF, and Si vs COM. (E)Bubble plot of multi-class KEGG pathway enrichment analysis in Figure
9D. (F) Summary diagram of KEGG pathway classification.(G) Heatmap of differential metabolites between Si group (n=5)
and COM group (n=5). (H) KEGG pathway analysis of differential
metabolites between Si group and COM group. (I) Venn diagram
showing the overlapping pathways among four comparisons, including PBS
vs Si, Si vs PFD, Si vs BIBF, and Si vs COM. (J) Bubble plot of
multi-class KEGG pathway enrichment analysis in Figure 9I.