Author Contributions
Chen Wang and Jing Wang conceived the idea and supervised the whole project. Meiyue Song contributed to the study design, participated in carrying out animal experiments, and revised the manuscript. Lu Bai and Xue Wang conducted animal experiments and contributed to data collection and analysis. Jiaxin Wang drafted and edited the article and participated the data analysis. Wei Zeng assisted with histological and molecular experiments. Jixin Wang and Junling Pang performed the RNA-seq analysis. Shengxi Li provided technical assistance with the metabolomics detection. Tiantian Zhang assisted with the data review and manuscript revision. The manuscript was approved by all authors.