Figure 9: Transcriptomic and metabolomic analysis jointly unveiled the mechanism of combination drug therapy for silicosis. (A)Heatmap of DEGs between Si group (n=6) and COM group (n=5), COM indicates low dose of combination drug therapy. (B) Volcano plot of DEGs between Si group and COM group. (C) KEGG pathway analysis of DEGs between Si group and COM group. (D) Venn diagram showing the overlapping pathways among four comparisons, including PBS vs Si, Si vs PFD, Si vs BIBF, and Si vs COM. (E)Bubble plot of multi-class KEGG pathway enrichment analysis in Figure 9D. (F) Summary diagram of KEGG pathway classification.(G) Heatmap of differential metabolites between Si group (n=5) and COM group (n=5). (H) KEGG pathway analysis of differential metabolites between Si group and COM group. (I) Venn diagram showing the overlapping pathways among four comparisons, including PBS vs Si, Si vs PFD, Si vs BIBF, and Si vs COM. (J) Bubble plot of multi-class KEGG pathway enrichment analysis in Figure 9I.