Figure 5: Mechanism investigation of PFD and BIBF against silicosis was indicated by metabolomics. (A) Heatmap of differential metabolites between PBS group (n=5) and Si group (n=5). (B)KEGG pathway analysis of differential metabolites between PBS group and Si group. (C) Heatmap of differential metabolites between Si group (n=5) and PFD group (n=5). (D) KEGG pathway analysis of differential metabolites between Si group and PFD group. (E)Heatmap of differential metabolites between Si group (n=5) and BIBF group (n=5). (F) KEGG pathway analysis of differential metabolites between Si group and BIBF group. (G) Venn diagram showing the overlapping pathways among three comparisons, including PBS vs Si, Si vs PFD, and Si vs BIBF. (H) Bubble plot of multi-class KEGG pathway enrichment analysis in Figure 5G. The highlighted pathways refer to the intersection of three comparisons.