Figure 4: Transcriptomic analysis revealed distinct and shared mechanisms underlying PFD and BIBF treating silicosis. (A) Flowchart of mechanism exploration by transcriptomic and metabolomic analysis.(B) Heatmap of DEGs (P -values< 0.05) between PBS group (n=5) and Si group (n=6). (C) Volcano plot representing the analysis of DEGs between PBS group and Si group. KEGG pathway analysis of downregulated DEGs (D) and upregulated DEGs(E) between PBS group and Si group. (F) Heatmap of DEGs between Si (n=6) group and PFD group (n=7). (G) Volcano plot of DEGs between Si group and PFD group. (H) KEGG pathway analysis of DEGs between Si group and PFD group. (I) Heatmap of DEGs between Si group (n=6) and BIBF group (n=4). (J) Volcano plot of DEGs between Si group and BIBF group. (K) KEGG pathway analysis of DEGs between Si group and BIBF group. (L)Venn diagram showing the overlapping pathways among three comparisons, including PBS vs Si, Si vs PFD, and Si vs BIBF. (M) Bubble plot of multi-class KEGG pathway enrichment analysis in Figure 4L.