Key Results
Both pirfenidone and nintedanib were demonstrated to be effective for
advanced silicosis, with superior outcomes when used in combination.
Transcriptomic and metabolomic analyses revealed that pirfenidone and
nintedanib primarily exerted their therapeutic effects through
modulation of immune responses, signaling cascades, circadian rhythm,
and metabolic processes of substances including lipid, amino acids,
nucleotides, and carbohydrates.