Association between the number of live births and aging
The estimated values of FI, ΔKDM-biological age and HD for each pairty after multiple covariates corrections calculated using a general linear model are presented in a box plot in Figure 2, which shows the results of the relationship between the number of live births and biological aging. As shown in Figure 2 and Supplementary table 4, the estimated FI, ΔKDM-biological age and HD box charts for two or three live births are located at the lowest position, while the corresponding box charts for five or more live births are located at the highest position; and the corresponding box charts for zero, one, and four live births is located between these above. In other word, the estimated values of FI, ΔKDM-bioage and HD adjusted for multiple covariates of mothers with two or three children were lower, and the correspondings of mothers with five or more children were higher, comparied with females who had one children (all P for trend<0.001).