Background: Pediatrics with cancer have higher mortality and morbidity rates than reported in general pediatrics who got infected by COVID-19, vaccination is a priority. Method: A random sample of 409 parents of pediatrics with cancer have been recruited, after obtaining IRB approval. A self-administered web-based cross-sectional survey was completed by them, and their demographic data have been collected as well. Results: Parents’ age and their pediatrics’ age play a significant role in their willingness to vaccinate their pediatrics who had cancer with the COVID-19 vaccine. Conclusion: A large proportion of parents are hesitant about the COVID-19 vaccine because they are less confident in its effectiveness, safety, and whether it is essential for their pediatrics. Keywords: COVID-19 vaccine; Cancer; Pediatrics; Vaccine hesitancy; Pediatric oncology.