Objective To evaluate the immune effect of the COVID-19 vaccination in patients with coronary artery disease. Methods One hundred and fifty patients were randomly selected among patients with coronary heart disease, including 100 in the vaccination group and 50 in the control group. A retrospective cohort study was conducted to investigate the infection rate of the two groups of people infected with the SARS-CoV-2 during its outbreak and the occurrence of related symptoms after infection. Results The infection rate of the inoculated group and the control group was 91% and 62%, respectively，and the difference was statistically significant（X 2=4.854，P＜0.05）. The incidence of myalgia was 62.6% and 41.9%, respectively，and the difference was statistically significant（X 2=4.052，P＜0.05）. The probability of nasal congestion and rhinorrhea was 46.2% and 22.6%, respectively，and the difference was statistically significant（X 2=5.347，P＜0.05）. Conclusion On patients with coronary heart disease, the COVID-19 vaccine had a relatively poor immunological response.